SUMMARY OF TOXICOLOGY DATA Fipronil
نویسندگان
چکیده
DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Fipronil Chemical Code # 3995, Tolerance # 52062 SB 950 # NA Original: April 26, 2005 Revised: December 12, 2006, July 16, 2010, 12/20/10, 3/25/11 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, possible adverse effect indicated Chronic toxicity, dog: No data gap, possible adverse effect indicated Oncogenicity, rat: No data gap, possible adverse effect indicated Oncogenicity, mouse: No data gap, possible adverse effect indicated Reproduction, rat: No data gap, no adverse effect Teratology, rat: No data gap, no adverse effect Teratology, rabbit: No data gap, no adverse effect Gene mutation: No data gap, no adverse effect Chromosome effects: No data gap, no adverse effect DNA damage: No data gap, no adverse effect Neurotoxicity: No data gap, possible adverse effect indicated in rat acute neurotoxicity study*
منابع مشابه
Survival, growth, and body residues of hyalella azteca (Saussure) exposed to fipronil contaminated sediments from non-vegetated and vegetated microcosms.
We assessed chronic effects of fipronil and metabolite contaminated sediments from non-vegetated and Thallia dealbata vegetated wetland microcosms on Hyalella azteca during wet and dry exposures. Mean sediment concentrations (ng g(-1)) ranged from 0.72-1.26, 0.01-0.69, 0.07-0.23, and 0.49-7.87 for fipronil, fipronil-sulfide, fipronil-sulfone, and fipronil-desulfinyl, respectively. No significan...
متن کاملFipronil-induced disruption of thyroid function in rats is mediated by increased total and free thyroxine clearances concomitantly to increased activity of hepatic enzymes.
Fipronil is a widely used phytosanitary product and insecticide for pets. In the rat, fipronil can disrupt thyroid function by decreasing plasma concentrations of total thyroxine (T4) likely through increased T4 clearance. However, the mechanism of fipronil action on thyroid function remains unclear. The goals of the present study were to evaluate the effects of fipronil on thyroid hormone (TH)...
متن کاملAbiotic processes influencing fipronil and desthiofipronil dissipation in California, USA, rice fields.
Fipronil insecticide dissipated in California rice fields, producing half-lives of 10.5 to 125 h in water and 44.5 to 533 h in soil, depending on the formulation applied and the resulting differences in water solubility. The major degradation products were desthiofipronil in water and fipronil-sulfide in soil, while the sulfone and amide were less abundant. Fipronil was photolyzed rapidly to de...
متن کاملAcute enantioselective toxicity of fipronil and its desulfinyl photoproduct to Ceriodaphnia dubia.
Fipronil is a phenylpyrazole insecticide increasingly used in applications such as rice culture, turf grass management, and residential pest control, with a high probability to contaminate aquatic environments. As a chiral pesticide, fipronil is released to the environment as a racemic mixture (equal amounts of optical isomers called enantiomers). Enantiomers can have different toxicological an...
متن کاملFipronil promotes adipogenesis via AMPKα-mediated pathway in 3T3-L1 adipocytes.
Emerging evidence suggests that organochlorine, organophosphorus and neonicotinoid insecticide exposure may be linked to the development of obesity and type 2 diabetes. However, there is no knowledge of the potential influence of fipronil, which belongs to the phenylpyrazole chemical family, on obesity. Thus, the goal of this study was to determine the role of fipronil in adipogenesis using 3T3...
متن کامل